BDC Laboratories in Scientific Literature

BDC Laboratories’ test equipment and simulated use systems are widely used by leading researchers and engineers focused on cardiovascular device design and development. Our solutions have been referenced in numerous peer-reviewed publications, highlighting their critical role in scientific research.

If you have published research or technical papers that reference BDC Laboratories equipment or services, we invite you to contact us to be included in our growing list of cited publications.

To explore peer-reviewed articles that reference BDC Laboratories, we encourage you to search Google Scholar.

Development of 3D-Printed Flow-Diverting Stents for Studying the Effect of Aneurysm Treatment In Vitro

Bautz L, Oni OA, Sarwar T, Toraman H, Jansen O, Hövener JB, et al. Annals of 3D Printed Medicine [Internet]. 2025 May;18:100196.

This study developed a protocol for fabricating 3D-printed FD replicas to test customized FDs and support MR imaging development by providing a metal-free testing platform.

A Technique for Intra-Procedural Blood Velocity Quantitation Using Time-Resolved 2D Digital Subtraction Angiography

Hoffman C, Periyasamy S, Longhurst C, Medero R, Roldan-Alzate A, Speidel MA, et al. CVIR Endovasc [Internet]. 2021 Jan 7;4(1):11.

[The purpose of this study is to] assess the accuracy and precision of a quantitative 2D DSA (qDSA) technique and to determine its feasibility for in vivo measurements of blood velocity.

Arterial Stiffness Assessment Using PPG Feature Extraction and Significance Testing in an In Vitro Cardiovascular System

Ferizoli R, Karimpour P, May JM, Kyriacou PA. Sci Rep [Internet]. 2024 Jan 23;14(1):2024.

This study employs a custom-manufactured in vitro cardiovascular system with vessels of varying stiffness to test the hypothesis that PPG signals may be used to detect and assess the level of arterial stiffness under controlled conditions.

Motion-Robust, Blood-Suppressed, Reduced-Distortion Diffusion MRI of the Liver

Geng R, Zhang Y, Rice J, Muehler MR, Starekova J, Rutkowski DR, et al. Motion‐robust, blood‐suppressed, reduced‐distortion diffusion MRI of the liver. Magnetic Resonance in Med [Internet]. 2023 Mar [cited 2025 May 8];89(3):908–21.

[The purpose of this study is to] evaluate feasibility and reproducibility of liver diffusion-weighted (DW) MRI using cardiac-motion-robust, blood-suppressed, reduced-distortion techniques.

A Technique for Intra-Procedural Blood Velocity Quantitation Using Time-Resolved 2D Digital Subtraction Angiography

Hoffman C, Periyasamy S, Longhurst C, Medero R, Roldan-Alzate A, Speidel MA, et al. CVIR Endovasc [Internet]. 2021 Jan 7;4(1):11.

[The purpose of this study is to] assess the accuracy and precision of a quantitative 2D DSA (qDSA) technique and to determine its feasibility for in vivo measurements of blood velocity.

Customisable Silicone Vessels and Tissue Phantoms for In Vitro Photoplethysmography Investigations into Cardiovascular Disease

Karimpour P, Ferizoli R, May JM, Kyriacou PA. Sensors [Internet]. 2024 Mar 5;24(5):1681.

The primary objective of this study was to explore how changes in silicone formulations influenced vessel properties and their correlation with features extracted from signals obtained from photoplethysmography (PPG) reflectance sensors in an in vitro setting.

Pulsatile Flow Testing of Heart Valve Prostheses In Vitro

Kaule S, Lange V, Ott R, Borowski F, Bohne E, Oldenburg J, et al. Current Directions in Biomedical Engineering [Internet]. 2022 Sep 2;8(2):683–6.

In this work, two pulse duplicator systems at our institute (2x BDC Laboratories, Wheat Ridge, CO, USA) were evaluated according to the new ISO [5840:2021] standard. The results obtained were compared intra-institutionally between the different test benches and internationally with the round-robin study to validate the developed test methodology regarding the normative requirements.

Effects of Contact Pressure in Reflectance Photoplethysmography in an In Vitro Tissue-Vessel Phantom

May JM, Mejía-Mejía E, Nomoni M, Budidha K, Choi C, Kyriacou PA. Sensors [Internet]. 2021 Dec 16;21(24):8421.

This study explores a controlled in vitro study to investigate the effect of continually applied contact pressure on PPG signals (signal-to-noise ratio (SNR) and 17 morphological PPG features) from an artificial tissue-vessel phantom across a range of simulated blood pressure values.

Design and Validation of a High-Fidelity Left Atrial Cardiac Simulator for the Study and Advancement of Left Atrial Appendage Occlusion

Mendez K, Singh M, Willoughby P, Ncho B, Liao A, Su S, et al. Cardiovasc Eng Tech [Internet]. 2025 Jan 27.

This study introduces a novel left atrial cardiac simulator that incorporates patient-derived LAA models within a benchtop circulatory flow loop, enabling high-fidelity LAAO device testing and development.

Influence of Spatial Resolution and Compressed SENSE Acceleration Factor on Flow Quantification with 4D Flow MRI at 3 Tesla

Pravdivtseva MS, Gaidzik F, Berg P, Ulloa P, Larsen N, Jansen O, et al. Tomography [Internet]. 2022 Feb 10;8(1):457–78.

Here, we investigated the effect of spatial resolution and CS acceleration on flow measurements by using 4D flow MRI in small vessels in vitro at 3 T.

In Vitro Hemodynamic Performance of a Blood Pump for Self-Powered Venous Assist in Univentricular Hearts

Rasooli R, Holmstrom H, Giljarhus KET, Jolma IW, Vinningland JL, de Lange C, et al. Sci Rep [Internet]. 2024 Mar 23;14(1):6941.

This study experimentally validates the effectiveness of an intracorporeally-powered venous ejector pump (VEP) in reducing IVC pressure in Fontan patients.

TCT-374 Redo Transcatheter Aortic Valve Replacement With the Novel DurAVR Valve: Insights From the Bench

Sathananthan J, Sellers S, Hahn R, Cavalcante J, Asgar A, Latib A, et al. Journal of the American College of Cardiology [Internet]. 2023 Oct;82(17):B149–50.

In this in vitro bench study, we compared the hydrodynamic performance of DurAVR with other commercially available THVs simulating redo transcatheter aortic valve replacement (TAVR).

Ex-Vivo and In-Vivo Validation of Novel Quantitative Videodensitometric Assessment of Mitral Regurgitation Following Surgical Mitral Valve Replacement

Serruys P, Kawashima H, Ono M, Aben JP, Pighi M, Soliman O, et al. Structural Heart [Internet]. 2021 Jun;5:58.

[The objective of this study is to] investigate the accuracy and interobserver variability of Quantitative videodensitometric assessment of Mitral Regurgitation (QMR) after mitral valve replacement in a preclinical ovine model.

Thin-Film Patient-Specific Flow Diverter Stents for the Treatment of Intracranial Aneurysms

Velvaluri P, Pravdivtseva MS, Berg P, Wodarg F, Miranda RLD, Hövener J, et al. Adv Materials Technologies [Internet]. 2021 Sep;6(9):2100384.

Here a workflow to design, fabricate, and characterize novel thin-film FDs that can be individualized to meet patient-specific needs is demonstrated.

Interleaved X-Ray Imaging: A Method for Simultaneous Acquisition of Quantitative and Diagnostic Digital Subtraction Angiography

Whitehead JF, Hoffman CA, Wagner MG, Minesinger GM, Nikolau EP, Laeseke PF, et al. Medical Physics [Internet]. 2024 Apr;51(4):2468–78.

The purpose of this study is to demonstrate an interleaved x-ray imaging method which decreases the radiation dose rate associated with high frame rate qDSA while simultaneously providing low frame rate diagnostic DSA images, enabling the acquisition of both datasets in a single image sequence with a single injection of contrast agent.

Effective orifice diameter: a new sizing parameter of surgical valve prostheses to inform valve selection

Wu C, Green C, Marquez S, Monelli P, Weinberg C, Weston M, et al. Ann Cardiothorac Surg [Internet]. 2024 May;13(3):283–90.

The ISO Cardiac Valves Working Group conducted a multi-laboratory round-robin study to investigate whether the effective orifice diameter of a prosthetic surgical valve could be derived repeatably and reproducibly through steady forward-flow testing. A total of seven valve models, each with multiple sizes, were tested, including a mechanical heart valve and multiple biological heart valves.

Experimental and Computational Study of Pulsatile Flow Characteristics in Romanesque and Gothic Aortic Arch Models

Zhang Y, Zhang R, Thomas N, Ullah AH, Eichholz B, Estevadeordal J, et al. Medical Engineering & Physics [Internet]. 2022 Apr;102:103784.

To understand the fluid dynamic signatures of such flow, a combined experimental and computational fluid dynamic (CFD) study has been conducted to quantitatively compare the main (axial) and secondary flow characteristics.